In vivo, a CB1 antagonist blocked the seizure – induced DSI potentiation, the associated upregulation of CB1 receptors, and diminished long-term hippocampal excitability.. Kang Chen, Axel Neu, Allyson L. Csaba F ldy, Julio Echegoyen, Lutz Hilgenberg, Martin Smith, Ken Mackie and Ivan Soltesz?Although febrile seizures are common in childhood and often benign, prolonged febrile seizures have long-term consequences. Prolonged febrile seizures paradoxically increase hippocampal GABA release and decrease seizure threshold. In this week’s Journal, Chen et al.
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